Chloroquine is an aminoquinoline that is quinoline which is substituted at position 4 by a [5- (diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment …

2019年2月28日 · Chloroquine is a weak base with pKa values of 8.1 and 10.2 and the protonation of the drug encharged at the neutral pH of the blood. With the acidic pH for parasite food …

2014年1月1日 · Hydroxychloroquine has three basic functional groups with pKa values of <4.0, 8.3 and 9.7, two of which would be protonated at pH 7.4. Similarly, chloroquine has three pKa …

氯喹（Chloroquine）是一种抗疟药。 主要对疟原虫的红内期起作用，能有效地控制疟疾症状发作。 对红外期无作用，不能阻止复发，但因作用较持久，故能使复发推迟，因恶性疟无红外 …

Based on literature review, it is proposed that the coadministration of drugs that modulate CYP2C8, CYP3A4, and CYP2D6 could have potential effects on the PK of chloroquine. 42 …

氯喹可通过抑制Toll样受体、内溶酶体活性、炎性细胞因子的释放、NADPH氧化酶（NOX）的活性以及钙（Ca²⁺）信号等多种途径协同减少促炎细胞因子的产生和释放，发挥免疫调节作用。 …

1984年1月1日 · Chloroquine is white or slightly yellow crystalline powder, which is odorless and bitter in taste. It is very slightly soluble in water but soluble in dilute acids, chloroform, and …

The pKa values of the conjugate acids of the antimalarial drug chloroquine were determined at various temperatures using fluorescence spectrophotometry and nonlinear regression in the …

Chloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria. 4 It was the drug of choice to treat malaria until the development of newer …

1984年1月1日 · Chloroquine possesses two basic ionization sites with pKa values of 8.1 and 10.4 [27]. Hence, dicationic conjugated acid chloroquine forms phosphate salt by attaching with …