H. pylori, a dominant human pathogen, is now recognized as the first member of an ultrastructurally diverse genus. The predominant morphological form of this genus is curved to spiral; however, some members have either a short or tapered rod shape. All helicobacters are motile by means of flagella.

Helicobacter pylori is a Gram-negative, microaerophilic bacterium colonising the gastric mucosa. Normally, this bacterium has a spiral shape, which is crucial for proper colonisation of the stomach and cork-screwing penetration of dense mucin covering this organ.

2024年11月21日 · Morphology of Helicobacter pylori. Helicobacter pylori is a Gram-negative bacterium with distinctive features that make it highly adapted to its environment. Its unique structure plays a critical role in its mobility and survival.

Virulence factors identified in H. pylori. The curved morphology of H. pylori and the polar motility caused by flagella in one end cause screw-like movements, which may enable the organism to penetrate the mucin layer.

2019年7月7日 · The stomach ulcer and cancer-causing pathogen Helicobacter pylori has a helical cell shape which facilitates stomach infection. Using light scattering to measure perturbations of cell morphology, we identified 28 genes that influence different aspects of cell shape.

Helicobacter pylori cell shape mutants uncover a helical cell shape promoting “shapesome” complex. A. H. pylori, like all helical organisms has a minor helical axis defined by the shortest helical path between the two poles and a longer major helical axis 180 degrees opposite.

2024年1月3日 · The helical Helicobacter pylori relies on its unique shape for survival and efficient colonization of the human stomach. Yet, they have been observed to transform into another distinctive morphology, the spherical coccoid.

Using single-cell tracking and quantitative morphology analysis we document marked variation in cell body helical parameters and flagellum number among H. pylori strains leading to distinct and broad speed distributions in broth and viscous gastric mucin media.

Helicobacter pylori is a spiral-shaped bacterium causing peptic and gastric ulcers, linked to stomach cancer. It survives stomach acidity by producing urease, creating an alkaline environment. Spread via fecal-oral route, it induces inflammation in the gastric mucosa.

While important findings about the physiology and genetics of H. pylori are summarized in this volume, it also includes sections on epidemiology, bacteriology, bacterial virulence and pathogenic mechanisms, pathogenesis in the host, diagnosis and treatment, animal models, and other Helicobacter species.