Irbesartan | C25H28N6O | CID 3749 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

IUPAC name for irbesartan is 2 butyl-3 - ( {4- [2- (2H-1,2,3,4-tetrazole-5-il) phenyl] phenyl} methyl) -1,3-diazaspiro [4.4] non-1-en-4-one (C 25 H 28 N 6 O). The structural formula for...

Irbesartan, sold under the brand name Aprovel among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. [5] It is a reasonable initial treatment for high blood pressure. [5] It is taken by mouth. [5] Versions are available as the combination irbesartan/hydrochlorothiazide. [5] [6] [7] [8]

Irbesartan merupakan zat yang bersifat amfoter atau membentuk zwitter ion akibat adanya gugus imidazolinon (pKa= 3,60) yang bersifat basa dan gugus tetrazol (pKa= 4,7) yang bersifat asam (35 ...

The article also discusses the methods for preparation of irbesartan, its physical-chemical properties, analytical methods for its determination, pharmacological-toxicological properties, and ...

Irbesartan (IBS), a poorly water-soluble drug used in the treatment of hypertension,17 exhibits desmotropy, the property of tautomers to crystallize as two different crystal structures. Recently, the effect of solvent polarity on the selectively obtained form A and form B has been investigated,18 as well as

2022年4月19日 · Irbesartan (2-butyl-3-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diaaspiro[4.4]non-1-en-4-one, C25H28-N6O), a highly selective angiotensin II receptor (AT1) antagonist was found to exist in two distinct crystal forms (A and B). This paper describes the crystal structure of irbesartan form B. Crystallog. data are given.

2019年10月1日 · Irbesartan (IBS) is a tetrazole derivative and antihypertensive drug that has two interconvertible structures, 1H- and 2H-tautomers. The difference between them lies in the protonation of the tetrazole ring. In the solid-state, both tautomers can be isolated as crystal forms A (1H-tautomer) and B (2H-tautomer).

Serum levels of the advanced glycation end products Nepsilon-carboxymethyllysine and pentosidine are not influenced by treatment with the angiotensin receptor II type 1 blocker irbesartan in patients with type 2 diabetic nephropathy …

The present work describes the development and validation of a stability-indicating RP-HPLC method for the estimation of degradation and process related impurities of Irbesartan, namely...