Adaptive designs in clinical trials: why use them, and how to run …
2018年2月28日 · We explain the basic rationale behind adaptive designs, clarify ambiguous terminology and summarise the utility and pitfalls of adaptive designs. We discuss practical aspects around funding, ethical approval, treatment supply and communication with stakeholders and trial participants.
Adaptive design methods in clinical trials – a review
2008年5月2日 · Based on adaptations applied, adaptive designs can be classified into three categories: prospective, concurrent (ad hoc), and retrospective adaptive designs. An adaptive design allows modifications made to trial and/or statistical procedures of ongoing clinical trials.
[2501.06252] $\text{Transformer}^2$: Self-adaptive LLMs - arXiv.org
2025年1月9日 · Self-adaptive large language models (LLMs) aim to solve the challenges posed by traditional fine-tuning methods, which are often computationally intensive and static in their ability to handle diverse tasks. We introduce $\\text{Transformer}^2$, a novel self-adaptation framework that adapts LLMs for unseen tasks in real-time by selectively adjusting only the singular components of their weight ...
What Are Adaptive Platform Clinical Trials and What Role May …
2022年2月28日 · The term “adaptive” implies that key features of the trial design are modified during the trial in response to accumulating information for the purpose of maximizing statistical efficiency or achieving better outcomes for trial participants. 1 For example, response-adaptive randomization (RAR) allows randomization ratios to be altered to ...
Designing and conducting adaptive trials to evaluate …
2022年7月1日 · Adaptive trials incorporate changes as the study proceeds, such as modifying allocation probabilities or eliminating treatment arms that are likely to be ineffective. These designs have been widely used in drug discovery studies but can also be useful in health services and implementation research and have been minimally used.
Efficient Adaptive Designs for Clinical Trials of Interventions for ...
These challenges make adaptive designs for clinical trials a particularly attractive option. Such designs allow a trial to be modified on the basis of interim analysis data or stopped as soon as sufficiently strong evidence has been observed to answer the research question, without compromising the trial’s scientific validity or integrity.
Adapting and Adaptive Research - SpringerLink
2024年4月24日 · Adapting research entails choosing different research designs or methods if research goals, contexts or constraints justify or require a different approach. Adaptive research, by contrast, is a type of research that prospectively plans for modifications after research has been initiated, while maintaining the validity and integrity of the research.
Adding flexibility to clinical trial designs: an example-based guide …
2020年11月19日 · In a traditional clinical trial, the design is fixed in advance, the study is carried out, and the data analysed after completion [1]. In contrast, adaptive designs pre-plan possible modifications on the basis of the data accumulating over …
Adaptive designs in clinical trials: why use them, and how to ... - PubMed
2018年2月28日 · Adaptive designs can make clinical trials more flexible by utilising results accumulating in the trial to modify the trial's course in accordance with pre-specified rules. Trials with an adaptive design are often more efficient, informative and ethical than trials with a traditional fixed design sin …
Adaptive Clinical Trial Design | Nature Research Intelligence
Adaptive clinical trial design is an innovative approach that allows researchers to modify various aspects of a trial based on interim results. This flexibility can lead to more efficient trials ...