Alcohol, liver disease and the gut microbiota - PubMed
This Review focuses on clinical studies involving the gut microbiota in patients with alcoholic liver disease across the spectrum from alcoholic fatty liver to cirrhosis and alcoholic hepatitis. Specific alterations in the gut-liver-brain axis that are complicit in the interactions between the gut microbiota and alcohol addiction are also reviewed.
Alcohol, liver disease and the gut microbiota | Nature Reviews ...
2019年1月14日 · This Review focuses on clinical studies involving the gut microbiota in patients with alcoholic liver disease across the spectrum from alcoholic fatty liver to cirrhosis and...
Roles of Gut Microbiota in Alcoholic Liver Disease - PMC
2023年8月23日 · Alcohol consumption induces a weakened gut barrier and changes in the composition of the gut microbiota. The presence of CYP2E1 and its elevated levels in the gastrointestinal tract after alcohol exposure lead to elevated levels of ROS and acetaldehyde, inducing inflammation and oxidative damage in the gut.
Gut microbiota in alcohol-related liver disease: pathophysiology …
2023年8月4日 · Gut metabolites as protective factors in ALD. Bile acids positively correlates with the histological severity of liver inflammation via the activation of various nuclear receptors, such as FXR. CDCA and UDCA of mice were decreased with the progression form non- hepatitis to sAH. Associated with a low level of VLDL and a high level of HDL.
The gut–liver axis and gut microbiota in health and liver disease
2023年6月14日 · Patients with alcohol-associated liver disease have a dysbiotic gut microbiota that is generally characterized by decreased bacterial diversity, increased proportions of pathobionts such...
Alcohol, the gut microbiome, and liver disease - PubMed
2023年4月25日 · In this review, we summarize the bacterial, fungal, and viral gut microbial compositional changes associated with alcohol use and alcohol-associated liver disease and discuss the mechanisms of action by which gut dysbiosis reinforces alcohol use behavior and liver inflammation and injury.
Gut microbiota in alcoholic liver disease: Pathogenetic role and ...
2014年11月11日 · Several studies have demonstrated the importance of gut-liver axis and new treatments have been studied in recent years to reduce progression of ALD modifying gut microbiota. It has focused attention on antibiotics, prebiotics, probiotics and synbiotics.
Roles of Gut Microbiota in Alcoholic Liver Disease
2023年8月23日 · Alcohol consumption induces a weakened gut barrier and changes in the composition of the gut microbiota. The presence of CYP2E1 and its elevated levels in the gastrointestinal tract after alcohol exposure lead to elevated levels of ROS and acetaldehyde, inducing inflammation and oxidative damage in the gut.
Links of gut microbiota composition with alcohol dependence …
2017年10月17日 · Gut microbiota has been implicated in the pathogenesis of alcohol-related liver diseases, with its composition manifesting expressed dysbiosis in patients suffering from alcoholic dependence. Due to its inherent plasticity, gut microbiota is an important target for prevention and treatment of these diseases.
Inflammation and gut microbiota in the alcoholic liver disease
After alcohol stimulation, the metabolites of gut microbiota will change, and then create a vicious cycle to liver. In brief, the application and translation of the current review promises new approaches in the treatment of ALD, especially from inflammasomes and gut microbiota.</p>
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