Science Forum: Antibody characterization is critical to enhance
2024年8月14日 · Antibodies are critical reagents used in a variety of assays and protocols in biomedical and clinical research. The ability to detect, quantify, enrich, localize, and/or perturb the function of a target protein – even when present in a complex protein mixture, such as a cell lysate or tissue slice, or even in an intact organism – is key to many biomedical research studies.
Research Articles - eLife
2025年1月2日 · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware ...
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eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science.
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eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd ...
How to measure and evaluate binding affinities | eLife
2020年8月6日 · We analyzed 100 papers reporting K D or ‘apparent K D ’ values of RNA/protein interactions. Measurements were evaluated based on two criteria: demonstrating equilibration (horizontal axis) and controlling for titration (vertical axis).
Genome-wide mapping of native co-localized G4s and R-loops in …
2024年10月11日 · The DNA G4-hemin complex could act as a mimic peroxidase to oxidize the biotin tyramide to phenoxyl radicals that can covalently conjugate biotin to G4 itself and its proximal DNA within ~30 bp in the presence of H 2 O 2 (Cheng et al., 2009; Einarson and Sen, 2017; Lat et al., 2020).However, the efficiency of peroxidase-mediated biotinylation on DNA is limited using the substrate biotin ...
Gene Fusion: Decoding the identity of rare tumors | eLife
2024年10月7日 · Gene fusions are common mutations that have been linked to several types of cancer, most notably chronic myelogenous leukemia, which is a result of the BCR gene on chromosome 22 fusing with the ABL gene on chromosome 9 (Nowell and Hungerford, 1960).Identifying fusion genes, and investigating the molecular behavior of the chimeric fusion proteins that arise from these mutations, may help with ...
Latest research | eLife
2024年12月12日 · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware ...
Magazine - eLife
2024年12月23日 · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware ...
Single-cell characterization of menstrual fluid at homeostasis and …
2024年11月19日 · eLife Assessment. This basic research study presents useful data concerning the menstrual fluid composition and its potential for endometriosis biomarker research. However, despite solid bioinformatics analyses, the choice of markers used to separate or identify the different cell types needs to be justified and the results better discussed in relation to current knowledge of the ...