2024年9月9日 · In-Depth [randomized controlled trial]: This phase 3, multicenter, open-label trial enrolled adults with stage IV clear-cell renal-cell carcinoma who had disease progression after treatment with immunotherapy and a VEGFR-TKI and randomized them (1:1) to belzutifan (n=374) or everolimus (n=372). Median follow-up time was 18.4 months for the first interim analysis and 25.7 months for the second ...

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2023年3月8日 · 1. For patients diagnosed with breast cancer liver metastases (BCLM), liver function tests were found to be elevated at 6 months prior to detection of metastases. Evidence Rating Level: 2 (Good) Breast malignancy is one of the leading causes of cancer-related mortality in women, and 20-30% of patients develop metastases. The liver is a common

2024年9月23日 · Relevant Reading: The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe? In-Depth [randomized controlled trial]: This international, double-blind study enrolled patients with NSCLC, pancreatic cancer, or colorectal cancer with defined cachexia and an elevated serum GDF-15 level, and randomized them (1:1:1:1) to ponsegromab at a dose of 100 mg (n=46), 200 mg (n=46), or 400 mg ...

2024年12月16日 · 1. Median progression-free survival was 9.4 months in the imlunestrant–abemaciclib group vs 5.5 months in the imlunestrant group with HR 0.57 (significant) and 5.6 months in the imlunestrant group vs 5.5 months in the standard-therapy group with HR 0.87 (non-significant). 2. With regards to safety, adverse …

2024年11月29日 · 1. A history of endometriosis and uterine fibroids in women was associated with a greater risk of premature mortality and mortality due to gynecological cancers. 2. A history of endometriosis in women was associated with a greater risk of non-cancer mortality. Evidence Rating Level: 2 (Good) Endometriosis and uterine fibroids are common disorders among women

2024年11月16日 · 1. In this randomized clinical trial comparing the use of pelvic floor muscle training (PFMT) alone to PFMT with a biofeedback (BF) device, the use of PFMT with BF was superior in reducing stress urinary incontinence (SUI) in postpartum women. Evidence Rating Level: 1 (Excellent) Stress urinary incontinence (SUI) is a pelvic floor dysfunction disorder

2024年12月10日 · 1. Treatment of patients with tyrosine kinase inhibitor (TKI)-naïve epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) with osimertinib and ramucirumab resulted in a significantly longer progression-free survival (PFS) compared with osimertinib alone. Evidence Rating Level: 1 (Excellent) Study Rundown: The current standard of care for patients with advanced EGFR ...

2024年10月28日 · 1. The use of glucagon-like peptide 1 (GLP-1) receptor agonists in adults with type 2 diabetes mellitus (T2DM) was not associated with increased risks of pulmonary aspiration during upper gastrointestinal endoscopy discontinuation compared to the use of sodium-glucose cotransporter 2 (SGLT-2) inhibitors. 2. The use of GLP-1 receptor agonists among adults with T2DM was associated

2024年10月11日 · 1. Among patients with hereditary hemorrhagic telangiectasia (HHT), pomalidomide significantly reduced the severity of epistaxis and improved quality of life. 2. Pomalidomide was associated with neutropenia, constipation, and rash. Evidence Rating Level: 1 (Excellent) Study Rundown: HHT is a common inheritable bleeding disorder characterized by fragile telangiectasias and arteriovenous ...